Example: Epithelial-Mesenchymal Transition (EMT) ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^ When a cell transitions from an epithelial cell to a mesenchymal cell, it is a hallmark of cancer. The cell loses its orderly, cube-like shape from its epithelial phenotype to a mesenchymal cell that has increased migrational capacity. The mesenchymal cell may be elongated and fragment away from its neighbors to prepare for intravasation. .. image:: images/epithelial_mesenchmal_diagrams.png :alt: Epithelial and Mesenchymal Cell Diagrams :width: 80% `Download the sample code here `_, then watch the video from the latest workshop to follow along: `Get the slides here `_. .. image:: https://img.youtube.com/vi/PsidmqgQppc/maxresdefault.jpg :alt: Workshop Tutorial Video :target: https://www.youtube.com/watch?v=PsidmqgQppc&list=PLiEtieOeWbMKTIF2mekBc9cABFPEDwCdj&index=18&t=513s :width: 80% .. [Last Updated] October 2023 Key Takeaways: * Increasing contact energy between cells of the same type will move the cells apart * Decreasing contact energy between the mesenchymal cell and the medium will also help those cells move apart * Very high or low contact energy may cause cells to tear apart